The Multifunctional Mesencephalic Locomotor Region
Identifieur interne : 001039 ( Main/Exploration ); précédent : 001038; suivant : 001040The Multifunctional Mesencephalic Locomotor Region
Auteurs : Dimitri Ryczko [Canada] ; Réjean Dubuc [Canada]Source :
- Current pharmaceutical design : (Print) [ 1381-6128 ] ; 2013.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
In 1966, Shik, Severin and Orlovskii discovered that electrical stimulation of a region at the junction between the midbrain and hindbrain elicited controlled walking and running in the cat. The region was named Mesencephalic Locomotor Region (MLR). Since then, this locomotor center was shown to control locomotion in various vertebrate species, including the lamprey, salamander, stingray, rat, guinea-pig, rabbit or monkey. In human subjects asked to imagine they are walking, there is an increased activity in brainstem nuclei corresponding to the MLR (i.e. pedunculopontine, cuneiform and subcuneiform nuclei). Clinicians are now stimulating (deep brain stimulation) structures considered to be part of the MLR to alleviate locomotor symptoms of patients with Parkinson's disease. However, the anatomical constituents of the MLR still remain a matter of debate, especially relative to the pedunculopontine, cuneiform and subcuneiform nuclei. Furthermore, recent studies in lampreys have revealed that the MLR is more complex than a simple relay in a serial descending pathway activating the spinal locomotor circuits. It has multiple functions. Our goal is to review the current knowledge relative to the anatomical constituents of the MLR, and its physiological role, from lamprey to man. We will discuss these results in the context of the recent clinical studies involving stimulation of the MLR in patients with Parkinson's disease.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000037
- to stream PascalFrancis, to step Curation: 000B81
- to stream PascalFrancis, to step Checkpoint: 000045
- to stream Main, to step Merge: 001052
- to stream Main, to step Curation: 001039
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">The Multifunctional Mesencephalic Locomotor Region</title><author><name sortKey="Ryczko, Dimitri" sort="Ryczko, Dimitri" uniqKey="Ryczko D" first="Dimitri" last="Ryczko">Dimitri Ryczko</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Groupe de Recherche sur le Système Nerveux Central, Département de physiologie, Université de Montréal</s1><s2>Montréal</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Groupe de Recherche en Activité Physique Adaptée, Département de kinanthropologie, Université du Québec à Montréal</s1><s2>Montréal</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region><settlement type="city">Montréal</settlement></placeName><orgName type="university">Université du Québec à Montréal</orgName></affiliation></author><author><name sortKey="Dubuc, Rejean" sort="Dubuc, Rejean" uniqKey="Dubuc R" first="Réjean" last="Dubuc">Réjean Dubuc</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Groupe de Recherche sur le Système Nerveux Central, Département de physiologie, Université de Montréal</s1><s2>Montréal</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Groupe de Recherche en Activité Physique Adaptée, Département de kinanthropologie, Université du Québec à Montréal</s1><s2>Montréal</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region><settlement type="city">Montréal</settlement></placeName><orgName type="university">Université du Québec à Montréal</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">14-0057761</idno><date when="2013">2013</date><idno type="stanalyst">PASCAL 14-0057761 INIST</idno><idno type="RBID">Pascal:14-0057761</idno><idno type="wicri:Area/PascalFrancis/Corpus">000037</idno><idno type="wicri:Area/PascalFrancis/Curation">000B81</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000045</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000045</idno><idno type="wicri:doubleKey">1381-6128:2013:Ryczko D:the:multifunctional:mesencephalic</idno><idno type="wicri:Area/Main/Merge">001052</idno><idno type="wicri:Area/Main/Curation">001039</idno><idno type="wicri:Area/Main/Exploration">001039</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The Multifunctional Mesencephalic Locomotor Region</title><author><name sortKey="Ryczko, Dimitri" sort="Ryczko, Dimitri" uniqKey="Ryczko D" first="Dimitri" last="Ryczko">Dimitri Ryczko</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Groupe de Recherche sur le Système Nerveux Central, Département de physiologie, Université de Montréal</s1><s2>Montréal</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Groupe de Recherche en Activité Physique Adaptée, Département de kinanthropologie, Université du Québec à Montréal</s1><s2>Montréal</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region><settlement type="city">Montréal</settlement></placeName><orgName type="university">Université du Québec à Montréal</orgName></affiliation></author><author><name sortKey="Dubuc, Rejean" sort="Dubuc, Rejean" uniqKey="Dubuc R" first="Réjean" last="Dubuc">Réjean Dubuc</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Groupe de Recherche sur le Système Nerveux Central, Département de physiologie, Université de Montréal</s1><s2>Montréal</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Groupe de Recherche en Activité Physique Adaptée, Département de kinanthropologie, Université du Québec à Montréal</s1><s2>Montréal</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region><settlement type="city">Montréal</settlement></placeName><orgName type="university">Université du Québec à Montréal</orgName></affiliation></author></analytic><series><title level="j" type="main">Current pharmaceutical design : (Print)</title><title level="j" type="abbreviated">Curr. pharm. des. : (Print)</title><idno type="ISSN">1381-6128</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Current pharmaceutical design : (Print)</title><title level="j" type="abbreviated">Curr. pharm. des. : (Print)</title><idno type="ISSN">1381-6128</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Acetylcholine</term><term>Locomotion</term><term>Nucleus</term><term>Parkinson disease</term><term>Review</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Locomotion</term><term>Nucleus</term><term>Acétylcholine</term><term>Maladie de Parkinson</term><term>Article synthèse</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In 1966, Shik, Severin and Orlovskii discovered that electrical stimulation of a region at the junction between the midbrain and hindbrain elicited controlled walking and running in the cat. The region was named Mesencephalic Locomotor Region (MLR). Since then, this locomotor center was shown to control locomotion in various vertebrate species, including the lamprey, salamander, stingray, rat, guinea-pig, rabbit or monkey. In human subjects asked to imagine they are walking, there is an increased activity in brainstem nuclei corresponding to the MLR (i.e. pedunculopontine, cuneiform and subcuneiform nuclei). Clinicians are now stimulating (deep brain stimulation) structures considered to be part of the MLR to alleviate locomotor symptoms of patients with Parkinson's disease. However, the anatomical constituents of the MLR still remain a matter of debate, especially relative to the pedunculopontine, cuneiform and subcuneiform nuclei. Furthermore, recent studies in lampreys have revealed that the MLR is more complex than a simple relay in a serial descending pathway activating the spinal locomotor circuits. It has multiple functions. Our goal is to review the current knowledge relative to the anatomical constituents of the MLR, and its physiological role, from lamprey to man. We will discuss these results in the context of the recent clinical studies involving stimulation of the MLR in patients with Parkinson's disease.</div></front></TEI><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université du Québec à Montréal</li></orgName></list><tree><country name="Canada"><region name="Québec"><name sortKey="Ryczko, Dimitri" sort="Ryczko, Dimitri" uniqKey="Ryczko D" first="Dimitri" last="Ryczko">Dimitri Ryczko</name></region><name sortKey="Dubuc, Rejean" sort="Dubuc, Rejean" uniqKey="Dubuc R" first="Réjean" last="Dubuc">Réjean Dubuc</name><name sortKey="Dubuc, Rejean" sort="Dubuc, Rejean" uniqKey="Dubuc R" first="Réjean" last="Dubuc">Réjean Dubuc</name><name sortKey="Ryczko, Dimitri" sort="Ryczko, Dimitri" uniqKey="Ryczko D" first="Dimitri" last="Ryczko">Dimitri Ryczko</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001039 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001039 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Pascal:14-0057761
|texte= The Multifunctional Mesencephalic Locomotor Region
}}
| This area was generated with Dilib version V0.6.29. |  |